Open Access

This call is now closed. See the important documents and results below.

The Alliance4Life member institutions offer access to technologies and services in the area of life sciences and biomedical research to study biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes at different resolution levels, ranging from atomic to cellular with the aim of understanding the complexity of their structure and function.

What services do we offer?

We provide access to technologies (Core Facilities and shared laboratories) installed at the following research institutions. You can access their databases at the following links:

You can also access the shared database for all of these research institutions.

Who can use our services?

The call is intented only for Alliance4Life project partners, not for companies or external academics.

Applicants must be members of the Virtual Research Center (VRC). If you are not yet a member, please read about the membership and register at: Virtual Research Center by A4L

If you are commercial partner interested to use the infrastructure listed in the database please feel free to contact core facilities and shared laboratories to inquire about the specific services you plan to use. We will gladly prepare a customized quotation based on your requirements. Contact information of core facilities and shared laboratories can be found in the database of services offered.

2nd Call

This call is now closed. See the important documents and results below.

Important documents

Find the the documents necessary for successful reporting:

Results of the Call

The following projects have been selected for the open access:

Biomedical Research Center SAS

Uncovering Hidden Genetic Causes of Branchio-Oto-Renal Syndrome Using Long Read Sequencing
• Klaudia Cipkova
Dissecting the cellular basis of heterogeneous drug interaction phenotypes in patient-derived PDAC organoid-fibroblast co-cultures
• Maria Pacalajova
Epigenetic Dissection of CAF-Mediated Modulation of Therapy Response in PDAC
• Lenka Trnkova
Role of long non-coding RNA NRAD1 in colorectal cancer tumorigenesis
• Alexandra Repáková
The role of sulfide oxidation pathway in the regulation of hepatic mitochondrial homeostasis in metabolic syndrome
• Jakub Stepanovsky

Medical University of Lodz - MUL

Functional Role of SUMOylation of Cytoskeletal Proteins (Nestin and Vimentin) in the Progression and Phenotype of Glioblastoma Cells
• Wiktoria Dubanosow
Dissecting relaxin-2 and dexamethasone-driven gene expression programs in steroid-sensitive and resistant acute lymphoblastic leukemia
• Weronika Broszkiewicz

School of Medicine - University of Zagreb

Epigenetic Validation of a Down Syndrome–Derived Cerebral Organoid Model of Alzheimer’s Disease
• Jure Krasić
miRNAs and diabetes in heart failure
• Marko Borojević
Association between the proteomic profile of cholesteatoma and the clinical characteristics of chronic otitis media patients
• Filip Hergešić

University of Tartu

Dissecting the Role of mRNA Modification m6A in Neuronal Life and Death
• Kirill Matiitšin

1st Call

This call is now closed. See the important documents and results below.

Important documents

Find the the documents necessary for successful reporting:

Results of the Call

The following projects have been selected for the open access:

University of Ljubljana

Spatial characterization of biochemical and micromechanical alterations in deep fascia in type 2 diabetes mellitus using Raman-AFM combined microscopy.
- Contact: Chiedozie Kenneth Ugwoke
Unravelling the mechanisms of PLEC expression and release from wild-type and IF-null astrocytes.
- Contact: Borut Furlani

Biomedical Research Center SAS

Oxidative stress during metabolic cycle on DNA Transcription in yeast
- Contact: Miloslav Karhánek
Deciphering Cancer-Associated Fibroblast-Mediated Mechanisms Underlying the Effects of Combination Therapy Integrating DNMT Inhibitor Decitabine with Chemotherapy in PDAC
- Contact: Maria Urbanova
Detection of corridors and associated structures during apocrine secretion in Drosophila.
- Contact: Milan Beňo
Next-Generation Sequencing in Syndromic Hearing Loss Diagnostics
- Contact: Silvia Borecka
Validation of identified MASLD-specific EVs surface proteins by Atomic force microscopy (AFM)
- Contact: Zuzana Vince Kážmérová
Validation of identified MASLD-specific EVs surface proteins by Atomic force microscopy (AFM)
- Contact: Zuzana Vince Kážmérová
Expression of immune genes in human skin non-immune cells affected by TBEV infection
- Contact: Iveta Štibrániová
Identification of lncRNA Biomarkers for Metastatic Potential in Colorectal Cancer through RNA Expression Profiling
- Contact: Martina Poturnajova
The role and mutational profile of immune checkpoint molecules in hematologic malignancies.
- Contact: Katarína Lopušná
Examining the myeloma secretome in plasma through proteomic approaches
- Contact: Jana Jakubikova
Identification of TGF-β 1 binding molecule(s) in saliva of adult ticks Dermacentor reticulatus.
- Contact: Pavlína Bartíková

St. Anne's University Hospital Brno/ICRC

Modulating mitochondrial functions and mitophagy in glioblastoma cells and astrocytes
- Contact: Victorio Pozo Devoto

University of Tartu

Data acquisition and analysis of organelle transport in 3D organs via in vivo live imaging
- Contact: Juhan Pikamäe
Uncovering how depression and anxiety may increase risk of Parkinson’s disease
- Contact: Miriam Hickey
Analysis of eukaryotic ribosomal protein cleavage by viral protease
- Contact: Zuzana Vince Kážmérová

School of Medicine - University of Zagreb

Proteome DiSScovery: Proteomic study of blood plasma and extracellular vesicles in Interstitial lung disease associated with Systemic Sclerosis
- Contact: Stela Hrkač
Epigenetic profiling of human cerebral organoids – E-pro-Org
- Contact: Jure Krasić
The role of microRNAs in the diagnosis of kidney transplant antibody-mediated rejection and acute tubular necrosis
- Contact: Petar Šenjug